Brand name : TRXAMIC 500 (Tranexamic Acid, Cyklokapron)

TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Adult Dosing
Dosage forms: 500; IV
dental bleeding, hemophilia

25 mg/kg PO tid-qid x2-8 days
Start: 10 mg/kg IV x1 immed. preop; Alt: 25 mg/kg PO or 10 mg/kg IV tid-qid x2-8 days starting 24h before tooth extraction

*bleeding prophylaxis, post-cardiac bypass

1 mg/kg/h IV
Start: 10 mg/kg IV x1; Alt: 10-12.5 mg/kg IV x1 at induction, then 1-10 mg/kg x1 to prime pump, then 1-6.5 mg/kg/h IV; Info: protocols vary adjust dose amount, frequency
Cr 1.36-2.83: 10 mg/kg IV bid or 15 mg/kg PO bid; Cr 2.83-5.66: 10 mg/kg IV qd or 15 mg/kg PO qd; Cr >5.66: 10 mg/kg IV q48h or 5 mg/kg IV qd or 15 mg/kg PO q48h or 7.5 mg/kg PO qd; Info: recs apply to dental bleeding use only; adjustments not defined for other uses or IV infusion, conisder decr. Dose :

TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Peds Dosing
Dosage forms: 500; IV
dental bleeding, hemophilia<18 yo : Dose: 25 mg/kg PO tid-qid x2-8 days; Start: 10 mg/kg IV x1 immed. preop; Alt: 25 mg/kg PO or 10 mg/kg IV tid-qid x2-8 days starting 24h before tooth extraction *bleeding prophylaxis, post-cardiac bypass 2 mo-15 yo
Dose: 1 mg/kg/h IV; Start: 10 mg/kg IV x1; Alt: 10 mg/kg IV x1 at induction, then 1-10 mg/kg x1 on pump, then 10 mg/kg IV x1 at protamine; Info: protocols vary adjust dose amount, frequency
renal impairment: dose adjustment may be required although specific pediatric dosing adjustments not defined; see adult renal dosing for guidance

TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Contraindications/Cautions

* hypersens. to drug/class/compon. * color vision defect, acquired * subarachnoid administration * Factor IX use * anti-inhib. coag complex use * caution if renal dysfxn * caution if upper urinary tract bleeding * caution if thromboembolic dz hx * caution if DIC

TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Drug Interactions

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Avoid/Use Alternative :* anti-inhibitor coagulant complex

Caution Advised

* thrombolytics TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Adverse Reactions
Serious Reactions

* retinal degeneration * retinal vein thrombosis * retinal artery thrombosis * ureteral obstruction * thrombosis, venous * thrombosis, arterial * visual changes

Common Reactions

* nausea/vomiting * diarrhea * giddiness * hypotension * thromboembolism TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Safety Monitoring Monitoring Parameters: Cr at baseline, then in elderly pts cont. periodically; ophthal. exams at baseline and periodically thereafter if continual tx longer than several days

TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Pharmacology

Metabolism: liver minimally; CYP450: unknown

Excretion: urine (>95% unchanged); Half-life: 2h

Class: Bleeding Disorders

Mechanism Of Action inhibits plasminogen activators, interfering w/ fibrinolysis

TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Manufacturer/Pricing

Manufacturer: Pfizer U.S. Pharmaceuticals

DEA/FDA: Rx

TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Patient Education

Patient education material for this drug is not currently available.

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TRXAMIC 500 (Tranexamic Acid, Cyklokapron) Pill Pictures

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